07 May 2026
Case-based Conference returns on 3 to 4 November 2026 in Southampton, bringing together consultants and next generation rheumatologists to share clinical learning across adult and paediatric rheumatology.
This year’s programme will explore a wide range of complex and thought-provoking topics, including large vessel vasculitides, GCA and PMR, metabolic bone disorders, anti-phospholipid syndrome, Sjögren disease and paediatric rheumatology.
To help shape the programme, we’re inviting case submissions from across the rheumatology community. Whether your case raised diagnostic uncertainty, required multidisciplinary input, involved treatment challenges, or highlighted an unusual presentation, we want to hear from you.
Submission deadline: 10 July 2026, 23:59 BST
The prompts below are designed to help you think about the types of cases that could be submitted for this year’s sessions. They are not exhaustive, so please do share any case that has prompted discussion, changed practice, or offered valuable learning for colleagues.
Sjögren disease case prompts:
- Have you come across a case where it was difficult to distinguish primary Sjögren disease from other causes of sicca symptoms (e.g. medications, diabetes, fibromyalgia)?
- Have you managed a patient with seronegative Sjögren disease where diagnosis relied on biopsy or imaging?
- Do you have a case of Sjögren disease with overlap conditions (e.g. rheumatoid arthritis or SLE), and what made it complex?
- Have you seen a case where Sjögren disease presented mainly with extraglandular involvement (e.g. lung, renal, neurological)?
- Have you managed a patient with Sjögren disease who developed major complications such as lymphoma, and what were the early warning signs?
- Have you treated a case of Sjögren disease with significant organ involvement (e.g. ILD, renal tubular acidosis, neuropathy), and how did this affect management?
- Have you had a patient with Sjögren disease with persistent fatigue or pain despite controlled disease?
- Have you encountered difficulty monitoring Sjögren disease due to poor correlation between symptoms and biomarkers?
- Have you been involved in a case requiring multidisciplinary care (e.g. ophthalmology, oral medicine, respiratory)?
- Have you managed a case where treatment escalation (e.g. immunosuppressants or biologics) was challenging due to infection risk?
- Have you managed Sjögren disease in pregnancy, and how did concerns around anti-Ro antibodies and neonatal lupus influence care?
APS session case prompts:
- Do you have a case of treatment-refractory APS, with recurrent thrombosis despite standard therapy, and what strategies were used to manage this?
- Do you have an obstetric APS case, such as recurrent miscarriage, placental insufficiency, or early severe pre-eclampsia, where diagnostic uncertainty or high-risk management decisions made the case particularly challenging?
- Have you encountered catastrophic antiphospholipid syndrome, or a case in which CAPS was strongly suspected but an alternative diagnosis such as sepsis or thrombotic microangiopathy emerged, and how was this distinction made?
- Do you have a case of APS presenting with non-criteria or atypical features, for example livedo, thrombocytopenia, valvular disease, nephropathy, or neurocognitive symptoms, where recognition was delayed or management altered?
- Have you managed APS in association with systemic lupus erythematosus or another connective tissue disease where overlapping clinical features created diagnostic or therapeutic complexity?
- Do you have a case where laboratory uncertainty, for example transient antiphospholipid antibodies, or discordant results, had a significant impact on clinical decision making?
- Have you been involved in a case where multidisciplinary input, for example from haematology, obstetrics, stroke, renal, or intensive care teams, was critical to achieving a diagnosis or guiding management?
Metabolic bone disease case prompts:
- Do you have a case which has involved the assessment and management of metabolic bone disorders?
- Have you seen interesting cases of the following (but not restricted to) metabolic bone disorders as below?:
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- Fibrous Dysplasia
- Hereditary Hypophosphatasia
- Melorheosteosis
- Osteogenesis Imperfecta
- Osteomalacia
- Osteopetrosis
- Osteitis fibrosa
- Paget's disease
- Parathyroid disease
- Renal osteodystrophy
- Sarcopenia and bone disease
- Transient regional osteoporosis
- Tumour induced osteomalacia
- X-linked hypophosphatasia
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- Do you have any cases where specialised treatments have been used for the management of a metabolic disorder (e.g. Burosumab, Asfotase alfa)?
- Do you have any cases of treatments used for osteoporosis in the management of metabolic bone disorders?
PMR, GCA, or LVV case prompts
Do you have an interesting case:
- Where the diagnosis was unexpected, uncertain, delayed, or revised, including to or from a mimic?
- Significantly influenced by the presence/absence of a fast-track pathway or imaging?
- Highlighting the spectrum of PMR and GCA?
- where imaging was difficult to interpret or influenced management decisions, e.g., one that highlights the challenge of distinguishing inflammatory LVV from atherosclerosis or other mimics?
- where overlap with other autoimmune inflammatory conditions, infection or malignancy affected diagnosis and/or management?
- where the decision to initiate, escalate, or withhold treatment (including steroids, biologics, vascular intervention, or vascular surgery) was challenging?
- of refractory or relapsing disease despite standard or biologic therapy?
- with significant complications (e.g. vascular complications, steroid-related harm) that altered management?
- where treatment was complicated by toxicity, comorbidity, or when disease control and treatment harm posed competing risks that had to be balanced?
- that highlights the challenge of monitoring disease activity (e.g. the role of imaging or novel tools in monitoring relapse, or the challenge of differentiating relapse from steroid withdrawal or glucocorticoid-induced adrenal insufficiency)?
- that benefited from a multidisciplinary or non-standard management approach?
- where patient factors (e.g. preferences, risk tolerance, or psychosocial context) significantly influenced decision-making?
- That highlights reproductive issues in LVV?